A New Window into Huntington’s Disease: Neurofluid Pathways Go Awry
A new study reveals that Huntington’s disease (HD) is associated with significant structural and functional alterations in the brain’s neurofluid pathways. Using advanced MRI techniques, researchers found that individuals across the HD spectrum have enlarged choroid plexus and parasagittal dural spaces, reduced choroid plexus perfusion, and that these changes correlate with genetic severity and worse motor impairment. The findings suggest that disrupted cerebrospinal fluid production and outflow may contribute to neurodegeneration and could impact the delivery of future central nervous system-targeted therapies.
Why it might matter to you:
This work highlights a novel, system-level pathophysiological mechanism in neurodegeneration that extends beyond neuronal cells. For your focus on fluid biomarkers, it underscores the potential clinical value of integrating structural and functional imaging of neurofluid compartments with proteomic data to build a more comprehensive model of disease activity. Understanding these pathways could inform the development of diagnostic assays that track neurofluid dysregulation as a component of disease progression.
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