A 3D blueprint for ovarian cancer: Decellularised tissue models therapy response
Researchers have developed a novel three-dimensional model of high-grade serous ovarian cancer (HGSOC) metastasis using a decellularised peritoneal matrix. This advanced in vitro platform aims to more accurately replicate the complex tumor microenvironment of peritoneal carcinomatosis, a common and challenging pattern of spread. The model provides a valuable tool for investigating disease progression and, critically, for studying the response of metastatic cells to various therapeutic agents, bridging a gap between traditional cell cultures and in vivo studies.
Why it might matter to you: For pathologists focused on tumor biology and diagnostics, this model represents a significant step in translational research. It offers a sophisticated system to pre-clinically test how specific genetic mutations and biomarkers influence treatment efficacy in a realistic tissue context. This could directly inform the development of more targeted molecular diagnostics and help correlate histopathological findings from biopsies with predicted therapeutic outcomes, enhancing personalized treatment strategies.
Source →Stay curious. Stay informed — with Science Briefing.
Always double check the original article for accuracy.