The brain’s plumbing goes awry in Huntington’s disease
A new study reveals that Huntington’s disease (HD) is associated with significant structural and functional alterations in the brain’s neurofluid pathways. Researchers used advanced MRI techniques to show that individuals with HD have enlarged choroid plexus and parasagittal dural spaces, reduced choroid plexus perfusion, and that these changes correlate with greater genetic severity and worse motor impairment. The findings suggest that disrupted cerebrospinal fluid production and outflow may contribute to neurodegeneration and could impact the delivery of future central nervous system-targeted therapies.
Why it might matter to you:
This research provides a novel mechanistic framework linking fluid dynamics in the brain to neurodegenerative progression, a concept that may extend beyond HD to other conditions. For a neuroscientist investigating central nervous system function and therapeutic delivery, understanding these “neurofluid circuit aberrations” offers a fresh perspective on how the brain’s internal environment influences disease and treatment efficacy.
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